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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2024   |   Volume: 13   |   Issue: 1   |   Page: 1-5     View issue

Effect of Cisplatin Treatment on Interleukin-6 Gene Expression in Breast Cancer Cells: An In Vitro Study


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  1. Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, India.
  2. RNA Biology Lab, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, India.
  3. Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, India.
Abstract

Breast cancer stands as a pervasive cause of mortality among women globally, necessitating comprehensive investigations into its complex development and progression. This study aims to comprehend the complexities of breast cancer development, focusing on the roles of cell multiplication, movement, and the impact of cisplatin as a therapeutic agent. Additionally, it explores the significance of interleukin-6 (IL-6) in breast cancer, emphasizing the analysis of IL-6 gene expression changes pre and post-treatment using MTT assays and reverse transcriptase techniques. The research reveals that cisplatin effectively inhibits breast cancer cell proliferation, showcasing its therapeutic potential. The analysis of IL-6 gene expression demonstrates significant changes, offering insights into the molecular alterations induced by cisplatin and its impact on key signaling pathways associated with cancer progression. Major conclusions include the promising role of cisplatin in impeding breast cancer cell proliferation and its influence on the molecular landscape. The reduction in IL-6 gene expression post-treatment underscores cisplatin's multifaceted effects. The study highlights IL-6 as a potential biomarker for treatment response prediction, contributing valuable insights for personalized breast cancer treatment approaches.

Cite this article
Vancouver
Soni M, Parambath AK, Purayial ASUP, Ganapathy D, Sekar D. Effect of Cisplatin Treatment on Interleukin-6 Gene Expression in Breast Cancer Cells: An In Vitro Study. Clin Cancer Investig J. 2024;13(1):1-5. https://doi.org/10.51847/8XgcJrjExr
APA
Soni, M., Parambath, A. K., Purayial, A. S. U. P., Ganapathy, D., & Sekar, D. (2024). Effect of Cisplatin Treatment on Interleukin-6 Gene Expression in Breast Cancer Cells: An In Vitro Study. Clinical Cancer Investigation Journal, 13(1), 1-5. https://doi.org/10.51847/8XgcJrjExr

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ISSN Print: 2278-1668, Online: 2278-0513