TY  - JOUR
T1  - Effect of Cisplatin Treatment on Interleukin-6 Gene Expression in Breast Cancer Cells: An In Vitro Study
A1  - Muskan Soni
A1  - Ameya Kizhakke Parambath
A1  - Ashikha Shirin Usman Puthiya Purayial
A1  - Dhanraj Ganapathy
A1  - Durairaj Sekar
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2024
VL  - 13
IS  - 1
DO  - 10.51847/8XgcJrjExr
SP  - 1
EP  - 5
N2  - Breast cancer stands as a pervasive cause of mortality among women globally, necessitating comprehensive investigations into its complex development and progression. This study aims to comprehend the complexities of breast cancer development, focusing on the roles of cell multiplication, movement, and the impact of cisplatin as a therapeutic agent. Additionally, it explores the significance of interleukin-6 (IL-6) in breast cancer, emphasizing the analysis of IL-6 gene expression changes pre and post-treatment using MTT assays and reverse transcriptase techniques. The research reveals that cisplatin effectively inhibits breast cancer cell proliferation, showcasing its therapeutic potential. The analysis of IL-6 gene expression demonstrates significant changes, offering insights into the molecular alterations induced by cisplatin and its impact on key signaling pathways associated with cancer progression. Major conclusions include the promising role of cisplatin in impeding breast cancer cell proliferation and its influence on the molecular landscape. The reduction in IL-6 gene expression post-treatment underscores cisplatin's multifaceted effects. The study highlights IL-6 as a potential biomarker for treatment response prediction, contributing valuable insights for personalized breast cancer treatment approaches.
UR  - https://ccij-online.org/article/effect-of-cisplatin-treatment-on-interleukin-6-gene-expression-in-breast-cancer-cells-an-in-vitro-s-rh5bkvirfwr9ubb
ER  -