Submit Your Article CMED MEACR meeting
An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2023   |   Volume: 12   |   Issue: 3   |   Page: 1-5     View issue

Role of Ki-67 as an Adjunct to Histopathological Diagnosis in the Grading of Astrocytic Tumors


, , ,
Abstract

The Ki-67 Labelling Index (LI) is used as an ancillary tool to assess cell proliferation activity in glioma diagnosis. It is a potent biologic marker that estimates the growth of neoplasm and thus will aid in identifying the prognosis in patients with glioma. To study the expression of Ki-67 in astrocytic tumors and its correlation with clinicopathological parameters. Clinico-radiological details of forty-three cases of glioma were documented. H&E slides were reviewed for histopathological grade and morphology. KI-67 Labelling Index was studied by immunohistochemical analysis at ‘hot-spot’ areas. Cases were segregated into high and low grades taking 4% as a cut-off as per WHO criteria. Statistical analysis was carried out using standard statistical software with a p-value of ≤ 0.05 taken as statistically significant. A total of 43 patients were included comprising 31 males and 12 females with a mean age of 46.14 years. Ki-67 labeling index showed a statistically significant relationship with the advanced age (p=0.01), higher histological grade (p=<0.00001), presence of cellular atypia (p=0.0002), necrosis (p=<0.00001), and microvascular proliferation (p=<0.00001). Ki-67 assessment supplements standard histopathological grading. It is a simple and reliable method. This study demonstrates that it can serve as an important prognostic marker. It can be used as an adjunct to histopathological diagnosis.

Cite this article
Vancouver
Singh N, Pradhan P, Giri R, Satapathy D. Role of Ki-67 as an Adjunct to Histopathological Diagnosis in the Grading of Astrocytic Tumors. Clin Cancer Investig J. 2023;12(3):1-5. https://doi.org/10.51847/OeRauShySy
APA
Singh, N., Pradhan, P., Giri, R., & Satapathy, D. (2023). Role of Ki-67 as an Adjunct to Histopathological Diagnosis in the Grading of Astrocytic Tumors. Clinical Cancer Investigation Journal, 12(3), 1-5. https://doi.org/10.51847/OeRauShySy

Downloads: 253

Views: 1626
Copyright © 2024 Clinical Cancer Investigation Journal, All rights are reserved and for all open access contents, the Creative Commons licensing terms apply.
Online since 01 December, 2011
Creative Commons License 
ISSN Print: 2278-1668, Online: 2278-0513