TY  - JOUR
T1  - Role of Ki-67 as an Adjunct to Histopathological Diagnosis in the Grading of Astrocytic Tumors
A1  - Namita Singh
A1  - Prita Pradhan
A1  - Ranjana Giri
A1  - Diptiranjan Satapathy
JF  - Clinical Cancer Investigation Journal
JO  - Clin Cancer Investig J
SN  - 2278-0513
Y1  - 2023
VL  - 12
IS  - 3
DO  - 10.51847/OeRauShySy
SP  - 1
EP  - 5
N2  - The Ki-67 Labelling Index (LI) is used as an ancillary tool to assess cell proliferation activity in glioma diagnosis. It is a potent biologic marker that estimates the growth of neoplasm and thus will aid in identifying the prognosis in patients with glioma. To study the expression of Ki-67 in astrocytic tumors and its correlation with clinicopathological parameters. Clinico-radiological details of forty-three cases of glioma were documented. H&E slides were reviewed for histopathological grade and morphology. KI-67 Labelling Index was studied by immunohistochemical analysis at ‘hot-spot’ areas. Cases were segregated into high and low grades taking 4% as a cut-off as per WHO criteria. Statistical analysis was carried out using standard statistical software with a p-value of ≤ 0.05 taken as statistically significant. A total of 43 patients were included comprising 31 males and 12 females with a mean age of 46.14 years. Ki-67 labeling index showed a statistically significant relationship with the advanced age (p=0.01), higher histological grade (p=
UR  - https://ccij-online.org/article/role-of-ki-67-as-an-adjunct-to-histopathological-diagnosis-in-the-grading-of-astrocytic-tumors-djryctqeagm7pgt
ER  -