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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
Year: 2016   |   Volume: 5   |   Issue: 1   |   Page: 52-55     View issue

Multiple endocrine neoplasia-2A-revisited

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Multiple endocrine neoplasia-2A (MEN-2A) is a rare syndrome. MEN-2 is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. MTC is the most consistent feature in all subtypes of MEN-2. In MEN-2A, approximately 70–95% of individuals develop MTC, 50% develop pheochromocytoma, and 15–30% develop hyperparathyroidism. Identification of a germline REarranged in transfection mutation or the identification of the clinical features of MEN-2A in other first-degree relatives is required to make the diagnosis, in those patients with only one or two clinical features. We present the case of a family with MEN-2A syndrome. Here, the patient was first operated for MTC and following further investigation was detected to have pheochromocytoma. In her family history, she had a daughter who was earlier operated for MTC. After 5 years of follow-up, she is doing well. This is an additional case of MEN-2A.

Cite this article
Jena A, Patnayak R, Vaikkakara S, Sachan A, Vijaylaxmi B, Manilal B. Multiple endocrine neoplasia-2A-revisited. Clin Cancer Investig J. 2016;5(1):52-5.
Jena, A., Patnayak, R., Vaikkakara, S., Sachan, A., Vijaylaxmi, B., & Manilal, B. (2016). Multiple endocrine neoplasia-2A-revisited. Clinical Cancer Investigation Journal, 5(1), 52-55.

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ISSN Print: 2278-1668, Online: 2278-0513