%0 Journal Article
%T Multiple endocrine neoplasia-2A-revisited
%A Amitabh Jena
%A Rashmi Patnayak
%A Suresh Vaikkakara
%A Alok Sachan
%A Bodagala Vijaylaxmi
%A Banoth Manilal
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2016
%V 5
%N 1
%R 10.4103/2278-0513.172075
%P 52-55
%X Multiple endocrine neoplasia-2A (MEN-2A) is a rare syndrome. MEN-2 is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. MTC is the most consistent feature in all subtypes of MEN-2. In MEN-2A, approximately 70–95% of individuals develop MTC, 50% develop pheochromocytoma, and 15–30% develop hyperparathyroidism. Identification of a germline REarranged in transfection mutation or the identification of the clinical features of MEN-2A in other first-degree relatives is required to make the diagnosis, in those patients with only one or two clinical features. We present the case of a family with MEN-2A syndrome. Here, the patient was first operated for MTC and following further investigation was detected to have pheochromocytoma. In her family history, she had a daughter who was earlier operated for MTC. After 5 years of follow-up, she is doing well. This is an additional case of MEN-2A.
%U https://ccij-online.org/article/multiple-endocrine-neoplasia-2a-revisited-537