Submit Your Article CMED MEACR meeting
An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
JCR Impact Factor: 0.1
ARTICLE
Year: 2023   |   Volume: 12   |   Issue: 4   |   Page: 4-9     View issue

Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition


Magdalena Alvarez-Ramirez, Lauro Figueroa-Valverde, Francisco Diaz-Cedillo, Marcela Rosas-Nexticapa, Maria Lopez-Ramos, Virginia Mateu-Armand, Lopez-Gutierrez Tomas
Abstract

Several studies suggest that some drugs such as astemizole and tetrandine can inhibit the expression of Eag-1 in cancer cells. Analyzing these data, this study aimed to evaluate the theoretical interaction of furanone (compound 1) and its derivatives (compounds 2 to 30) with Eag-1 using the 7CN1 protein as a theoretical model; in addition, astemizole, tetrandine, N-(4-(2-(Diethylamino)ethoxy)phenyl)-2-nitro-4-(trifluoromethyl)-aniline (DNTA), 1-Dimethylamino-3-[4-(2-nitro-4-trifluoromethyl-phenyl-amino)-phenoxy]-propan-2-ol (ZVS-08), and 3-Chloro-N-{2-[3,5-dibromo-4-(3-di-methyl-amino-propoxy)-phenyl]-ethyl}-4-metho-xy-benzamide (PD) were used as controls in the DockingServer software. Results showed that interaction of compounds 1-30, DNTA, ZVS-08, and PD with 7CN1 protein surface involves different aminoacid residues. Besides, inhibition constant was lower for furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 compared to astemizole, tetrandine, DNTA, ZVS-08, and PD. These data suggest that furanone derivatives 7, 12, 16, 20, 25, 26, 29, and 30 could act as Eag-1 inhibitors in cancer cells. Therefore, these furenone derivatives could be good candidates for the treatment of cancer.

Cite this article
Vancouver
Alvarez-Ramirez M, Figueroa-Valverde L, Diaz-Cedillo F, Rosas-Nexticapa M, Lopez-Ramos M, Mateu-Armand V, et al. Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition. Clin Cancer Investig J. 2023;12(4):4-9. https://doi.org/10.51847/iVIQzRP5Lt
APA
Alvarez-Ramirez, M., Figueroa-Valverde, L., Diaz-Cedillo, F., Rosas-Nexticapa, M., Lopez-Ramos, M., Mateu-Armand, V., & Tomas, L. (2023). Theoretical Evaluation of Furanone and its Derivatives for the Treatment of Cancer Through Eag-1 Inhibition. Clinical Cancer Investigation Journal, 12(4), 4-9. https://doi.org/10.51847/iVIQzRP5Lt

Downloads: 17

Views: 18
Sitemap | What's New | Feedback | Copyright and Disclaimer | Privacy Notice
© Clinical Cancer Investigation Journal | Published by Polaris Publication
Online since 01 December, 2011
Editorial and Ethics Policies
Creative Commons  Open Access Journal View mobile site 
ISSN: Print -2278-1668, Online - 2278-0513