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Clinical Cancer Investigation Journal
Year: 2019   |   Volume: 8   |   Issue: 6   |   Page: 257-260     View issue

Squash cytology of langerhans cell histiocytosis of sellar region

Supriya Verma, Parinitha Sangam, Ravikala Rao

Langerhans cell histiocytosis (LCH) is a systemic disease, which usually involves the skeleton and skin of children with occasional involvement of the central nervous system (hypothalamo–pituitary axis). We report the case of a 16-year-old male with a space-occupying lesion (SOL) in the sellar region and diabetes insipidus. However, no systemic abnormality was noted. A clinical diagnosis of pituitary adenoma was given. However, on intraoperative consultation by squash smears, cells with nuclear grooves and few eosinophils were seen. Hence, a differential diagnosis of LCH was also given, which was confirmed by histopathology and immunohistochemistry. Hence, as a matter of fact, LCH should be considered as one of the rare differential diagnoses of SOL of sellar region.

Cite this article
Verma S, Sangam P, Rao R. Squash cytology of langerhans cell histiocytosis of sellar region. Clin Cancer Investig J. 2019;8(6):257-60.
Verma, S., Sangam, P., & Rao, R. (2019). Squash cytology of langerhans cell histiocytosis of sellar region. Clinical Cancer Investigation Journal, 8(6), 257-260.

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