Prevalence, Types, and Management of Maxillary Sinus Carcinoma: A Systematic Review

As Maxillary Sinus Carcinoma (MSC) is a rare and serious condition and due to the variable treatment modalities, that are seeking to manage it, this systematic review is to assess the prevalence, types, and effectiveness of Chemoradiotherapy (CRT) and Proton Therapy (PBT) in the management of MSC. PubMed, Web of Science, Science Direct, EBSCO, SCOPUS, Wiley, and Cochrane Library were searched. Study articles were screened by title and abstract using Rayyan QCRI then a full-text assessment was implemented. A total of twelve studies with 468 patients and 335 males were included. MSC was prevalent in Japan and SCC was the most common histopathological type of MSC, followed by adenoid cystic carcinoma. PBT is an effective therapeutic modality in managing MSC and offers a promising future in the treatment of head and neck cancer. Proton beam therapy's precise function will become clearer as it becomes more widely used and as clinical research's purview broadens. IMRT and CRT have high survival rates, good local control, and a low risk of recurrence. MSC was prevalent in Japan and SCC was the most common histopathological type of MSC.