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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2023   |   Volume: 12   |   Issue: 2   |   Page: 44-50     View issue

Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study


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Abstract

In fast-growing tumors such as locally advanced head and neck cancers (LA-HNC), hypofractionation effectively overcomes tumor repopulation. We aimed at evaluating the safety and efficacy of moderately hypofractionated radiotherapy with concurrent cisplatin in comparison to the conventional concurrent chemoradiotherapy (CCRT) in LA-HNC. Fifty-four patients with LA-HNC were randomized to receive either: 70Gy in 35 fractions in 7 weeks concurrently with weekly cisplatin 40 mg/m2 (Arm A), or 55Gy in 20 fractions in 4 weeks concurrently with weekly cisplatin 35mg/m2 (Arm B). Volumetric modulated arc therapy/ Intensity-modulated radiotherapy (VMAT/IMRT) plans were done for both arms. Local control (LC), acute toxicity, and progression-free survival (PFS) were recorded and compared between both arms.

A total of 34 patients were in arm A versus 20 patients in arm B, with a median follow-up period of 14.2 months (range 5.1-43.6 months). There was no significant difference in LC, PFS, or acute toxicity between both arms. Complete response occurred in 52.9%(18/34) and 45 %(9/20) in arm A and arm B respectively. In LA-HNC, moderate hypofractionation concurrently with cisplatin appears to be safe and feasible and is associated with a comparable response rate, PFS, and acute toxicity with conventional CCRT protocol.

Cite this article
Vancouver
Saad E, Kamaleldin M, Zaghloul A, Habib E, Mashhour K. Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study. Clin Cancer Investig J. 2023;12(2):44-50. https://doi.org/10.51847/VpFPXwghHC
APA
Saad, E., Kamaleldin, M., Zaghloul, A., Habib, E., & Mashhour, K. (2023). Hypofractionated Accelerated Radiotherapy with Concurrent Chemotherapy Versus Conventional Fractionation for LAHNSCC Using IMRT/VMAT: A Pilot Study. Clinical Cancer Investigation Journal, 12(2), 44-50. https://doi.org/10.51847/VpFPXwghHC

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ISSN Print: 2278-1668, Online: 2278-0513