Anatomopathological and Epidemiological Profile of Granulosa Tumors of the Ovary: About 9 Cases

Granulosa cell tumors are malignant tumors that belong to the tumors of the sexual cords and the stroma. This study permitted us to analyze the granulosa tumors of 9 cases based on the data of the literature. Eight patients presented with adult-type granulosa ovarian tumors and only one patient presented with the juvenile. Patients ranged between ages 29 to 75 age were predominantly postmenopausal women (77.77%). The first conditions found of discovery were tumor syndrome with abdominopelvic pain by the tumor syndrome with abdomino-pelvic pain in first place (77.77%) and abdomino-pelvic masses (55.55%), followed by endocrine syndrome with metrorrhagia (22.22%), and finally signs of dysuria in one patient. On histological examination, the majority of our patients presented a typical microscopic appearance with a tumor proliferation of diffuse architecture with the presence of nuclear grooves in all our patients and Call-Exner bodies in two-thirds. Treatment of these tumors typically involves surgical resection, with the extent of surgery dictated by the stage of disease and the presence of associated comorbidities. Adjuvant chemotherapy and/or radiation therapy may be considered in select cases, but the optimal management strategy for ovarian granulosa tumors remains poorly defined given the rarity of the disease and the lack of large-scale clinical trials.