α-Linalool from Coriander Root Inhibits the Proliferation and Invasion of a Human Gastric Cancer Cell Line

The goal of this study was to investigate the impact of coriander root extract on the migration and proliferation of the BGC-823 gastric cancer cell line, as well as to establish a theoretical and experimental foundation for the prevention and treatment of gastric cancer using coriander root. Clonal formation of BGC-823 cells was significantly reduced and cell proliferation was inhibited by coriander root extract; The invasion number of gastric cancer cells was reduced, the scratch healing ability was significantly reduced, and the cell migration ability was inhibited. The results showed that coriander root extract could inhibit the EMT process. After the action of coriander root extract, β-catenin and TGF-β/SMAD pathway genes like P-GSK-3β, TGF-β, and P-SMAD2/3 were decreased; The increased expression of SMAD2/3 and Gsk-3β suggested that coriander root extract may be mediated by β-Catenin and TGF-β/SMAD pathway regulated the proliferation and migration of BGC-823 cell of gastric cancer. Further analysis found that α- The human gastric cancer cell line BGC-823's growth and invasion were reduced by linalool. Coriander root extract, especially α-Linalool, which can be mediated by β-Catenin and TGF-β/SMAD pathway, inhibited the proliferation and migration of gastric cancer BGC-823 cells.