Acantholytic squamous cell carcinoma of the tongue: A diagnostic challenge

Squamous cell carcinoma is the commonest malignancy encountered in the head and neck. However, certain variants of this tumor can pose diagnostic dilemma due to their morphological mimicry. An incisional biopsy taken from a growth over the tongue presented with a similar diagnostic challenge. The unique histomorphological features of the rare acantholytic variant of squamous cell carcinoma and its differential diagnosis have been addressed in this report.