Traumatic Brain Injury Decreases NR2B GluR Levels in the Cerebral Cortex Neurons of C57BL/6 Mice

Traumatic brain injury (TBI) is one of the major medical problems in societies and a major cause of death and disability in developed and developing countries. One of the pathophysiological factors in TBI is the change in glutamate receptor levels in the brain following trauma. In the present study, it was hypothesized that a change in glutamate receptor levels in the cerebral cortex neurons of C57BL/6 mice was associated with traumatic brain injury (TBI). 32 C57BL/6 mice were divided into four groups of 24 hr, 48 hr, 72 hr, and 1 week with the same number (n = 8) in each group. Weight dropping model was used to cause brain injury. NR2B GluR levels in rat cortex tissue were measured by Western blotting. The results of Western blotting analysis showed a significant decrease in the NR2B GluR levels in 1 week after traumatic brain injury (TBI) compared to the control (ANOVA, p <0.05) (Cortex sham: 100±47, FP 93.8±4.8). There was no significant difference in other groups compared to the control group. The results of this study showed that Traumatic brain injury decreases the NR2B GluR levels.Traumatic brain injury decreases the NR2B GluR levels.