The Synergistic Effect of Zataria multiflora Extract on the Reduction of Ciprofloxacin Antibiotic Resistance through the Efflux Pump in Pseudomonas aeruginosa

Background and Objective: The huge costs of Pseudomonas aeruginosa strains’ antibiotic resistance , especially in immunocompromised are very important. The plant extracts such as the Zataria multiflora with their  compounds can have antibacterial effects against most Pseudomonas group bacteria and reduce their resistance. The current study aimed to investigate the synergetic effect of Zataria multiflora extract on reducing the resistance to Ciprofloxacin antibiotic in the Pseudomonas aeruginosa

 Method: The clinical strains have been collected and Province and identified after purification by biochemical methods. Evaluation of the Pseudomonas aeruginosa  resistance to ciprofloxacin was determined the presence and activity of the efflux pump in the bacteria in line with the antibiotic resistance.

Findings: It can be concluded from the current study that zattaria multiflura extract alone has an anti-microbial effect. Based on the results, it can be said that the ciprofloxacin-resistant Pseudomonas aeruginosa strains showed an acceptable reduction in drug resistance when the antibiotic was used simultaneously with the Zataria multiflora.

Conclusion: Based on the results, it can be said that the Zataria multiflora  extract alone can have an anti-microbial effect. when used simultaneously with the ciprofloxacin, it can increase the bacteria’s sensitivity to the antibiotic by affecting the function in the Pseudomonas aeruginosa, reducing the treatment duration, and decreasing the number of antibiotics  needed for treatment significantly.