The Pexiganan-Loaded Chitosan Nanoparticle: Preparation, Characterization and Antibacterial Activity on Helicobacter pylori

Helicobacter pylori is Gram-negative, spiral shape, as well as microaerophilic pathogen that be able to establish chronic gastrointestinal infection. H. pylori is linked with severe digestive disease i.e. peptic ulceration, as well as gastric adenocarcinoma. Herein, we designed and characterized sustained release nanoparticles of chitosan-pexiganan for possible elimination of H. pylori infection in mice model.