Dental prosthesis are potent to modify the balance of oral microbes by decreasing the salivary flow as well as plaque and calculus accumulation on the denture. This leads to the increase of bacterial, viral and fungal competition which can cause oral and systemic diseases including periodontal disease, tooth caries, type 2 diabetes, colon cancer, and could cause a negative effect on the digestive system, because the oral microbiome can be transferred from the oral cavity to the rest of GIT and lead to intestinal inflammation and other gut related disorders which finally can end to death.
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