Synchronous HPV-associated cancer of the cervix and anal canal in a non-HIV infected patient treated simultaneously

Synchronous malignancies are uncommon. The oncogenic viruses like Human Papilloma Virus (HPV) 16 and 18 have been implicated in the development of cancers of the cervix and anal canal and an increased risk occurs in Human Immunodeficiency Virus-infected (HIV) individuals. Though cervical screening for HPV infection is recommended in female patients with anal cancers, synchronous presentation of cancer cervix and anal canal is rare. We present a case of a 72-year-old lady with synchronous cancer cervix and anal canal with HPV 16 positivity by polymerase chain reaction (PCR) treated with external radiotherapy, followed by brachytherapy to both the sites.