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Over recent years, targeted therapy has become one of the most important innovations in cancer treatment. Agents targeting the epidermal growth factor receptor (EGFR) are administered in patients with advanced, recurrent or metastatic malignancy. We reported the case of a 74 year-old male patient with metastatic colorectal cancer who developed an SDRIFE and acneiform eruption during molecular target therapy with cetuximab and FOLFOX.