Submit Your Article CMED MEACR meeting
An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2019   |   Volume: 8   |   Issue: 2   |   Page: 47-51     View issue

Surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma: A meta-analysis


, , , ,
Abstract

Background: To find out whether surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma (OSCC). Materials and Methods: PubMed search was done to look for studies done on surgical margins and nodal metastasis of OSCC from 2008 to 2018. Results: Fixed effects meta-analysis showed a pooled estimate absolute risk reduction of −3% (95% confidence interval [CI] [−8, 2.5%]). P =0.2819 from the fixed margin model shows no statistically significant difference between close margins with cases of deaths due to recurrence or metastasis. The pooled odds ratio was 0.87 (95% CI 0.63–1.99, P = 0.3928) for the comparison between clear and closed margins for estimating the odds. It should be noted that the mean unweighted local recurrence rate for margins 5 mm or greater was 4.9% with 95% CI as −10.7%, 0.8%. Conclusion: The study shows that close surgical margins with nodal metastasis have a poor prognosis in OSCC; however, no statistical significance was seen in this meta-analysis.

Cite this article
Vancouver
Akheel M, George R, Jain A, Chahwala Q, Wadhwania A. Surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma: A meta-analysis. Clin Cancer Investig J. 2019;8(2):47-51. https://doi.org/10.4103/ccij.ccij_21_19
APA
Akheel, M., George, R., Jain, A., Chahwala, Q., & Wadhwania, A. (2019). Surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma: A meta-analysis. Clinical Cancer Investigation Journal, 8(2), 47-51. https://doi.org/10.4103/ccij.ccij_21_19

Copyright © 2024 Clinical Cancer Investigation Journal, All rights are reserved and for all open access contents, the Creative Commons licensing terms apply.
Online since 01 December, 2011
Creative Commons License 
ISSN Print: 2278-1668, Online: 2278-0513