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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
Year: 2013   |   Volume: 2   |   Issue: 4   |   Page: 281-286     View issue

Role of neoadjuvant chemotherapy in cancer cervix: A brief review

Aramita Saha, Anindya Mukherjee

Neoadjuvant chemotherapy (NACT) represents a promising modality apart from or radiotherapy as initial treatment of locally advanced cervical cancer. The primary objectives of NACT in the treatment of cervical cancer include improvement in tumor characteristics, to allow avoidance of radiotherapy, to prolong disease-free and overall survival, and facilitation of fertility-sparing surgery. Though several studies have shown promising results of NACT on tumor response, downstaging, decrease in local recurrence, improved progression free survival, yet its role is controversial and plenty of study results are waiting to establish its efficacy. After reviewing the available literatures in the internet, and focusing the light of our continuous 3 years experience, we have made an effort to find out the relevance of NACT in cancer cervix. NACT is feasible and produces impressive responses in cervical carcinoma, as has been demonstrated by several phase II and phase III trials. Some meta-analysis suggested that NACT followed by surgery improves overall survival compared with nonstandard radiotherapy alone.

Cite this article
Saha A, Mukherjee A. Role of neoadjuvant chemotherapy in cancer cervix: A brief review. Clin Cancer Investig J. 2013;2(4):281-6.
Saha, A., & Mukherjee, A. (2013). Role of neoadjuvant chemotherapy in cancer cervix: A brief review. Clinical Cancer Investigation Journal, 2(4), 281-286.

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