Role of long non-coding RNAs MIR22HG, LNCTAM34A, and TP53TG1 in Breast Cancer

Long non-coding RNAs (lncRNAs) like MIR22HG, LNCTAM34A, and TP53TG1 are dysregulated in a variety of cancers. In this study, we looked into how these lncRNAs affect breast cancer. Analysis of 150 breast tissues revealed a significantly decreased expression of the selected lncRNAs in tumor tissues than TANs (P < 0.05); this lower expression was linked to a graver patient survival rate. Suppression of cell cycle-related genes in human breast cancers suggests that MIR22HG may have a tumor suppressor function. This is supported by the fact that silencing of MIR22HG, LNCTAM34A, and TP53TG1 induced both cell survival and decreased programmed cell death through downregulation of the P53. According to our research, MIR22HG, LNCTAM34A, and TP53TG1 are down-regulated in breast cancer, and their suppression encourages the growth of breast cancer cells while preventing apoptosis. In addition, our results imply that MIR22HG, LNCTAM34A, and TP53TG1 may be used as novel diagnostic and prognostic markers for breast cancer as well as therapeutic targets.