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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ARTICLE
Year: 2019   |   Volume: 8   |   Issue: 6   |   Page: 236-240     View issue

Radiation-induced complication after radiotherapy in patients with head-and-neck cancers


Elaheh Kazemi, Farid Zayeri, Ahmad Baghestani, Mohsen Bakhshandeh, Maryam Hafizi
Abstract

Background: Exposure of nontarget organs such as the thyroid gland (as a normal and high radiosensitive tissue) to radiation during radiotherapy for patients with head-and-neck cancers remains unavoidable. Hypothyroidism is the most common radiation side effect on the thyroid gland. In this study, we used the parameters of thyroid gland (triiodothyronine [T3], thyroxine [T4], and thyroid-stimulating hormone [TSH]) measurements before and after radiotherapy for patients with head-and-neck cancers. Materials and Methods: In the first step, descriptive statistics for predictors and response variables were performed. In the next step of data analysis, a multivariate linear mixed-effects model was fitted simultaneously for three response variables in order to study the trend of thyroid gland parameters. Results: The results indicated that there was a significant decreasing trend in TSH from 1.74 at baseline to 0.65 at the end of the study, and there was a significant increasing trend in T4 from 8.63 at baseline to 9.38 at the end of the study. Conclusions: There were significant changes in thyroid gland parameters after radiotherapy treatment for patients with head-and-neck cancers. Thus, preventative strategies are needed to reduce this complication. The patients with head-and-neck cancers who received radiotherapy treatment should be evaluated regularly and repeatedly during the radiotherapy treatment period.

Cite this article
Vancouver
Kazemi E, Zayeri F, Baghestani A, Bakhshandeh M, Hafizi M. Radiation-induced complication after radiotherapy in patients with head-and-neck cancers. Clin Cancer Investig J. 2019;8(6):236-40. https://doi.org/10.4103/ccij.ccij_62_19
APA
Kazemi, E., Zayeri, F., Baghestani, A., Bakhshandeh, M., & Hafizi, M. (2019). Radiation-induced complication after radiotherapy in patients with head-and-neck cancers. Clinical Cancer Investigation Journal, 8(6), 236-240. https://doi.org/10.4103/ccij.ccij_62_19

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