With the COVID-19 outbreak, hospitalized patients with coronavirus may experience psychological symptoms. This study aimed to investigate the protective factors of anxiety and depression including coping, spiritual well-being, and psychological resilience. This was a descriptive and cross-sectional study and convenience sampling methods. The participants were 100 hospitalized patients from Tehran who were diagnosed with coronavirus by PCR test. There is a significant correlation between resilience and anxiety (r= -0.205, p-value <0.05), spiritual health and anxiety (r= -0.291, p-value <0.05), Coping and anxiety (r= 0.241, p-value <0.05), depression and anxiety (r= 0.997, p-value <0.001), resilience and depression (r= -0. 207, p-value <0.05), spiritual health and depression (r= -0.291, p-value <0.05) and coping and depression (r= 0.233, p-value <0.001). 94% of hospitalized patients with Covid-19 have moderate to severe depression and anxiety. Predictor variables could predict 0.169 of the anxiety score and 0.166 of the depression score by controlling demographic factors. The model is significant for both variables of anxiety F(3)= 7.688, P <0.001 and depression F(3)= 7.585, P <0.001. Linear regression analysis showed spiritual well-being (B= -0.092, standardized β= -0.298, P < 0.05), coping (B= 0.051, standardized β= -0.298, P < 0.05) were associated with anxiety scores. However, resilience (B= -0.071, standardized β= -0.178, P = 0.060), was not associated with depression scores. the results showed, a negative and significant relationship between resilience and spiritual well-being with depression and anxiety. Coping had a significant positive relationship with them.
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