Protective Effect of Honey and Grape Juice against Cisplatin-Induced Peripheral Neuropathy in Mice

Cisplatin, a potent chemotherapeutic agent, is widely used in the treatment of different types of solid tumors, and its neurotoxicity remains a major problem in clinical use. This study was designed to investigate the protective effect of honey and grape juice (GJ) against cisplatin-induced peripheral neuropathy.

A total of 40 mice were randomly divided into 5 equal groups (n = 8) including the control group; cisplatin group; GJ group; honey group; honey + GJ group. Cisplatin (2 mg kg-1 i.p.) was given twice a week six times. GJ (10%, 10 ml kg-1) and honey (10%, 10 ml kg-1) were orally given to mice every day. The tail-flick test was used to evaluate the neuroprotective properties of GJ and honey. Malondialdehyde (MDA) and total antioxidant capacity (TAC) were determined in the serum using colorimetric methods. Intraperitoneal injection of cisplatin meaningfully reduced the latency time in the tail-flick testas well as TAC in serum while increasing MDA. Orally treatment of mice with GJ, honey, and a combination of them increased latency time in the tail-flick testand TAC in serum, while decreasing the MDA levels. GJ, honey, and a combination of them can have protective effects against cisplatin-induced neuropathy, which may be due to the antioxidant properties of these substances.