Primary pleural synovial sarcomas (SSs) are rare tumors comprising <1% of all primary lung tumors. They are frequently misdiagnosed as relatively more common entities such as malignant mesothelioma. We present one such rare case of biphasic SS in the pleura of a 40-year-old female who presented with massive right hemothorax, and computed tomography revealed a pleural-based tumor in the right lung. Histopathological examination of the excised tumor was suggestive of biphasic SS. Immunohistochemical staining showed positivity with antibodies against cytokeratin 7, epithelial membrane antigen, vimentin, and bcl-2.
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