Primary pancreatic lymphoma in a human immunodeficiency virus-positive patient

Primary pancreatic lymphoma (PPL) is a rare occurrence. Lymphoma involving the pancreas may be seen more often. The incidence of non-Hodgkin′s lymphoma (NHL) is expected to increase in patients suffering from acquired immune deficiency syndrome (AIDS) and also as age increases that is beyond sixth decade. NHL involving the pancreas is often seen in AIDS patients; however, PPL in a human immunodeficiency virus patient is uncommon and consists of a handful of case reports. Obstructive jaundice as a presentation is unusual. Histological diagnosis is often required to differentiate it from pancreatic adenocarcinoma, though there are certain features on computerized tomography and magnetic resonance imaging that favor lymphoma. We here describe a case of PPL in a young patient of AIDS who presented with obstructive jaundice and a palpable lump. Radiological features suggested it to be an adenocarcinoma. However, biopsy and immunohistochemistry helped to get the final diagnosis.