Primary marginal zone lymphoma of the breast associated with hepatitis C virus infection: A rare case report and review of literature

Primary non-Hodgkin′s lymphoma of the breast is a rare entity, comprising <0.5% of all malignant tumors of the breast. They are mainly of the diffuse large B cell lymphoma, while marginal zone B cell lymphomas (MZLs) are exceedingly rare. Links between hepatitis C virus (HCV) infection and several non-Hodgkin lymphomas have been suggested by epidemiological studies. We herein report the first case of low grade MZL of the breast associated with HCV infection showing disease free recurrence following incomplete surgery and antiviral therapy. Nevertheless, the combination of chemotherapy and radiation therapy has been proposed as the gold standard treatment for primary breast lymphoma right now.