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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2022   |   Volume: 11   |   Issue: 3   |   Page: 1-8     View issue

p16INK4a, and p14ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip


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Abstract

The goal of this study was to clarify the role of p16INK4a, p14ARF, and p53 protein expressions in carcinogenesis in squamous cell carcinomas of the lip. The expressions of the p53, p16INK4a, and p14ARF proteins were examined in 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 cases of normal mucosa. Immunoreactivity in the peritumoral epithelium adjacent to squamous cell carcinomas was also evaluated. p16INK4a expression was increased in actinic cheilitis in comparison with normal mucosa (p=0.001). p14ARF expression progressively increased from normal mucosa to actinic cheilitis (p=0.001) and was observed to decrease significantly during the process of transition from actinic cheilitis to carcinoma (p=0.003). p53 values progressively increased from normal mucosa to actinic cheilitis (p=0.001) and carcinoma (p=0.008). A significant positive correlation was found between p14ARF and p53 in the peritumoral epithelium adjacent to carcinomas. Our findings indicated that p16INK4a and p14ARF immunohistochemistry does not determine whether or not actinic cheilitis has the potential to develop carcinoma. The p14ARF /p53 pathway is activated in the peritumoral epithelium adjacent to carcinoma; however, this activation would not be adequate to prevent carcinogenesis.

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Vancouver
Akatli AN, Ayva ES, Bozdogan O. p16INK4a, and p14ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip. Clin Cancer Investig J. 2022;11(3):1-8. https://doi.org/10.51847/vezzdfuPIf
APA
Akatli, A. N., Ayva, E. S., & Bozdogan, O. (2022). p16INK4a, and p14ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip. Clinical Cancer Investigation Journal, 11(3), 1-8. https://doi.org/10.51847/vezzdfuPIf

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ISSN Print: 2278-1668, Online: 2278-0513