Nasopharyngeal cancer with solitary femoral bone recurrence after 7 years

The skeleton is the most common site of distant metastasis from nasopharyngeal carcinoma. The commonly affected sites are the spine, and the pelvis and lesions are multifocal. However, solitary bone involvement with no evidence of loco-regional failure nor any other metastasis, 7 years after achieving a complete response to initial definitive chemoradiotherapy, is rare. We report the case of a 41-year-old man who developed a solitary femoral bone recurrence. He received local radiotherapy to the femur followed by cisplatin-based chemotherapy. He presently enjoys good functional status.