Investigating single nucleotide polymorphisms of ACE2 gene as a genetic factor in the control of COVID-19 infection

The severity of the coronavirus illness may be related to host genetic factors in 2019 (COVID-19). In viral cellulitis, angiotensin-converting enzyme 2 (ACE2) is crucial. The present literature aims to examine the relationship of COVID-19 mortality with rs2285666 and rs2074192 polymorphisms and clinical parameters..

ACE2 rs2285666 and 2074192 polymorphisms were genotyped using RFLP-PCR and Tetra-Arms methods in 556 recovered and 522 deceased patients.

  In deceased patients with ACE2 rs2285666 than they were with the TT genotype, both CC frequency and TT frequency were considerably higher, and vice versa for ACE2 rs2074192 than they were with the CC genotype. Higher levels of alanine aminotransferase, alkaline phosphatase, creatinine, erythrocyte sedimentation rate, and C-reactive protein and lower levels of uric acid, cholesterol, low-density lipoprotein, 25-hydroxyvitamin D, real-time PCR Ct values, and the CC genotype were linked to an increased risk of mortality, Based on the results of the multivariate logistic regression analysis..

The prevalence of the CC and TT alleles in ACE2 rs2285666 and ACE2 rs2074192, respectively, was found to be related to the clinical variables, death related to COVID-19, and these findings were supported by our findings. It will take more research to validate these findings.