Incidence, Pathology, and Ethnicity Pattern of Kidney Neoplasms in the Multi-ethnicity Country of Iran During 2008-2010

Our study aimed to analyze the rate of kidney neoplasm in Iran from 2008 to 2010, including its geographical and pathological specification, which has not been discussed before, and provincial distribution, as well as its possible relationship with ethnicity. We gathered the data from the nationwide Iranian cancer registry system during 2008-2010. Pathological information and tumor grade were extracted from scanned reports of patients’ pathology records, which a urologist reviewed. The incident rate (IR) of kidney cancer was 1.54, and the age-standardized rate (ASR) was 1.91 per 100000 cases during 2008-2010. The most prevalent Fuhrman grade was grade 2 (47.87%).T₁, T_2, and T₃ pathologies comprised 39.5%,30.1%, and 28% of the samples. The median [IQR]of reported tumors was 6.0[4.5-9.0] cm. The highest ethnic ASR of RCC was observed in the Kurd ethnicity (ASR: 2.26) and the lowest in the Baluch ethnicity (ASR: 0.94). The highest ASRs were reported in the provinces of Fars (ASR: 2.76), Tehran/Alborz (ASR: 2.62), and Kermanshah (ASR: 2.59), and the lowest in Ilam (ASR: 0.53), Golestan (ASR:0.86), North Khorasan (ASR:0.87), and Sistan-Baluchestan (ASR: 0.94). This is the first report to provide national data on the ethnicity and pathological characteristics of kidney cancer in Iran. The most prevalent pathology has been the T₁ stage, Fuhrman grade 2. Kurdish ethnicity revealed the highest ASR and the highest prevalence was reported in the Fars province.