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Background: Chronic gastritis (CG) is an inflammatory process that can lead to gastric cancer and Helicobacter Pylori (H. Pylori). In this study, immunohistochemical evaluation of P53 and Ki67 in biopsy samples of CG and gastric carcinoma patients with and without H. Pylori infection was investigated. Methods: From 82 archived paraffin blocks, 42 blocks were selected for CG group and 40 as the gastric cancer group. All CG and gastric cancer cases were subdivided into H. Pylori positive and negative subgroups. Monoclonal antibodies specific for Ki67 and P53 were used for immunohistochemical staining. Results: The results showed that differences of Ki67 and P53 expressions were statistically significant among patients with CG gastritis and gastric cancer (P < 0.05). However, there were not significant differences in Ki67 and P53 expression between H. Pylori-positive and H. Pylori-negative subgroups of gastritis and gastric cancer (P > 0.05). Conclusions: The present study proposed that P53 and Ki67 expressions changed in gastric cancer compared to the CG specimens. It seems that overexpression of these biomarkers probably has important roles in the route of carcinogenesis. Our results suggested that these overexpressions were not associated with H. Pylori infection. Further studies with larger sample size are needed in this field.
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