Giant cell carcinoma of uterus is an aggressive form of endometrial carcinoma. It can be confused on histopathology with other giant cell containing lesions including trophoblastic tumors, certain primary sarcomas, and malignant mixed müllerian tumors. Due to the paucity of cases of this rare subtype, the prognostic parameters are difficult to assess. We describe here one such case in a 60-year-old female who presented with postmenopausal bleeding. To the best of our knowledge, this is the 13th case being reported in world literature. We intend to describe this case due to its rarity, failure to recognize this tumor as a subtype, and lack of definition and guidelines in the literature for accurate classification.
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