Submit Your Article CMED MEACR meeting
An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ARTICLE
Year: 2019   |   Volume: 8   |   Issue: 6   |   Page: 215-221     View issue

Expression patterns of cofilin and scinderin in breast cancer and their association with clinicopathological features in Iranian patients


Parisa Nourmohammadi, Mojtaba Saffari, Mohammad Sheikhha, Sara Tutunchi, Bahareh Nourmohammadi, Amirnader Razavi, Reza Shirkoohi, Nasrin Ghasemi
Abstract

Background: Cofilin-1 (CLF1) and scinderin (SCIN) are significant actin-binding proteins that are involved in the regulation of the actin polymerization dynamics. Overexpression of CLF1 and SCIN has been associated with aggressive and tumorigenesis characteristics of various cancer types. The aim of the present study was to investigate the expression of CFL1 and SCIN genes in breast cancer cells and their association with clinicopathological features. Materials and Methods: In this study, 65 breast cancer tissues were randomly selected, and quantitative real-time polymerase chain reaction was performed to measure the expression level of CFL1 and SCIN genes in breast tumors. Then, the association of CFL1 and SCIN expression level with clinicopathological features was assessed using Prism 5 software. Results: Overexpression of CFL1 and SCIN was observed to be statistically significantly associated with tumor stage and lymph node involvement (P < 0.05). However, no association was found between the expression of the mentioned genes and tumor grade, tumor size, and patient age. Conclusion: The results of this study suggest that as CFL1 and SCIN genes may play a role in the development of breast cancer; they have the potential to be examined as new biomarkers to predict the progression of the mentioned disease.

Cite this article
Vancouver
Nourmohammadi P, Saffari M, Sheikhha M, Tutunchi S, Nourmohammadi B, Razavi A, et al. Expression patterns of cofilin and scinderin in breast cancer and their association with clinicopathological features in Iranian patients. Clin Cancer Investig J. 2019;8(6):215-21. https://doi.org/10.4103/ccij.ccij_52_19
APA
Nourmohammadi, P., Saffari, M., Sheikhha, M., Tutunchi, S., Nourmohammadi, B., Razavi, A., Shirkoohi, R., & Ghasemi, N. (2019). Expression patterns of cofilin and scinderin in breast cancer and their association with clinicopathological features in Iranian patients. Clinical Cancer Investigation Journal, 8(6), 215-221. https://doi.org/10.4103/ccij.ccij_52_19

Sitemap | What's New | Feedback | Copyright and Disclaimer | Privacy Notice
© Clinical Cancer Investigation Journal | Published by Polaris Publication
Online since 01 December, 2011
Editorial and Ethics Policies
Creative Commons  Open Access Journal View mobile site 
ISSN: Print -2278-1668, Online - 2278-0513