Evaluation of Mucoadhesive Films containing Electrospun Gellan Gum Nanofibers for Topical Use of Aphthous Stomatitis

Oral inflammation (Stomatitis) is a common disease of the mouth all over the world. The role of oxidative stress in the occurrence of these lesions has been suggested. The plant-derived biological compounds are an important branch of the medical treatment of diseases. The essential oil has antibacterial with antioxidant properties. In the current research, we want to design a system for the treatment of Aphthous Stomatitis using the Mucoadhesive property of polysaccharides in the form of nanofibers along with the loading of essential oil.

Polyvinyl alcohol nanofibers containing Gellan gum and essential oil were prepared by Electrospinning technique. They were cross-linked using glutaraldehyde to increase the stability of the fibers. The average size of nanofibers was measured by Scanning Electron Microscope. The release extract from the fibers was investigated in vitro. Finally, the antibacterial effect of the fibers was determined using the Inhibition zone

The nanofibers had an average size of 641 nm and a relatively uniform structure, and the release of the extract continued for more than 8 hours. In addition, the inhibition zone of Staphylococcus aureus bacteria was measured in this nanofiber of 15 mm. According to the results of this study, these nanofibers will be an effective tool for stomatitis treatment.