Evaluating the Effect of Injectable Use of Hydroalcoholic Extract of date (Phoenix Dactylifera) on Pentylene Tetrazole Induced Seizure in White Mice

Based on traditional medicine, dates have significant neurological and antioxidant properties. The present study was conducted to evaluate the therapeutic effects of hydroalcoholic extract of dates on pentylenetetrazole-induced seizures in Balb / c mice. In this experimental study, pentylenetetrazole (90 mg/kg) was used to induce a seizure. Mice were divided into eight groups. The case groups received the extract at concentrations of 30, 100, and 300 mg/kg, 45 minutes before injection, the control groups were divided into PTZ, PTZ and distilled water, PTZ and phenobarbital, and non-intervention groups. After PTZ injection, the onset, termination, and severity of seizure, as well as mortality of mice in different groups, were recorded and compared by the observer. The levels of sodium, potassium, calcium, phosphorus, and blood sugar in different groups were also assessed. At the end of the study, there was a significant difference between groups 1 and 3 (p <0.001), groups 3 and 4 (p <0.01), and groups 3 and 6 (p <0.05) in terms of seizure onset. The duration of seizures between groups 3 and 4 as well as groups 3 and 5 was also reported to be significant (p <0.05) and (p <0.001). In serum factors, the difference between sodium levels of groups 7 and 8 (p <0.05) and potassium levels of groups 2 and 5 (p <0.01) and 5 and 6 (p <0.01) was also significant. The results of this study showed that the hydroalcoholic extract of dates reduced the severity and duration of seizures in the study groups.