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Purpose: Cancer is a most important disease, and female reproductive system cancers are the most common cause of women mortality rate. Materials and Methods: This cross-sectional study analyzed medical record data for 4460 patients in Mazandaran population-based cancer registry. Results: The mean (standard deviation) age of these patients was 53.45 years, and the incidence rate of female reproductive cancers (age-standardized incidence rate) was 8.51 per 100,000 persons-year. These cancers incidences were more in urban than rural, but this difference was not significant. Differences between frequency of uterus and ovary cancers with tumor behavior are significant (P = 0.046). Conclusion: This certainly calls for further attention to preventive and treatment planning on female reproductive system cancers.