Design and use of pH-responsive polymers in drug delivery applications

Drug Delivery (DD) is an important matter in the pharmaceutical industry in recent decades. Scientists have found that the effectiveness of a drug can be influenced by how the drug is delivered to the body. A Targeted Drug Delivery (TDD) system enables doctors to deliver drugs to a precise part of the body (e.g. cancerous tumor). Also, it minimizes (or even eliminates) systemic side effects or damage to the tissues around the treatment site. The focus of the current study is on the most recent advancements in pH-responsive Polymer-Drug conjugates (PDC), including the activation mechanism, synthesis (generation), and description of particular features. Additionally, this research presents conjugate compounds with varied chemical structures and architectures as well as chosen samples from a variety of materials (such as books and articles). The conjugates of pH-responsive polymers and drugs are given a sneak peek. The design and development of drug pH-responsive polymers is a more intelligent platform for TDDs, according to a literature study, because of their well-established benefits, including controlled drug delivery (CDD), tumor-specific characteristics, intracellular drug delivery, and superior therapeutic effectiveness. Additionally, it removes MDR resistance and lessens both the drug's and the carrier's negative effects.