This study was conducted to determine the difference between the effect of cognitive-behavioral therapy (CBT) and positive psychotherapy on the locus of control in patients with hypothyroidism. This was a quasi-experimental study with a pretest-posttest-follow-up (PPF) design and a control group. The statistical population included all patients with hypothyroidism who one of the endocrinology clinics in Tehran in 2021, from which 60 patients were selected by convenience sampling and randomly assigned to CBT, positive psychotherapy, and control groups. The subjects answered the Rotter's Locus of Control Scale (1966) for pretest, posttest, and follow-up. The subjects in 2 experimental groups received 8 sessions of CBT and 8 sessions of positive psychotherapy. The data were analyzed using repeated-measures ANOVA. According to the results, there was no significant difference between the effect of CBT and positive psychotherapy on the locus of control in patients with hypothyroidism (P <0.05), and both methods significantly affected patients' locus of control. The results also indicated that CBT and positive psychotherapy significantly contributed to an increased patients 'locus of control and that CBT and positive psychotherapy could be used as adjuncts to pharmacotherapy in clinical settings to reduce the effects of hypothyroidism, enhance a locus of control, and focus on patients' internal attributions.
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