Comparison of the effect high protein diet on indicators related to ovarian aging in subjects at risk of premature ovarian failure

Introduction: we investigated the effects of high protein diet on the process of ovarian aging in subjects at risk of primary ovarian insufficiency.

Materials and Methods: The present study was conducted on 107 patients with early premature menopause. The patients were randomly assigned to three groups, including high-based animal protein diet group (Group A), high- based plant protein diet group (Group B) and  normal protein diet(a mixture of animal and plant proteins diet). Blood sampling and ultrasound tests were performed before and after six month.

Results: In group A, decreasing in FSH and increasing in AMH and inhibin A were observed (P <0.05). In the group B progesterone, AMH, and Inhibin A levels increased significantly, and FSH levels decreased significantly (P <0.05). In the group C the levels of estradiol and AMH increased significantly, and the levels of CRP decreased significantly (P <0.05).  The statistical test results show that AMH increase in all tree group and  FSH and estress decreased in all three groups. The intervention (six months) showed a significant difference among the three groups in terms of the presence of follicles. The group A showed a significant improvement in terms of the presence of follicles (P = 0.03).

Conclusion: Our findings reported a beneficial effect of a high-protein diet in improving the indicators affecting menopause in patients with premature menopause, also a remarkable improvement in hormones affecting ovarian function, however, high-base animal protein group showed better results than the other groups in terms of improving the number of follicles.