Comparison of side effects of risperidone fabricated by Bakhtar Biochemistry Factory with Risperdal produced by Janssen-Cilag Company, Belgium

This study aimed to compare the side effects of risperidone produced by Bakhtar Biochemistry Factory with Risperdal fabricated by Janssen-Cilag Co., Belgium. Twenty-two patients diagnosed with schizophrenia based on DSM-IV-TR criteria and defined inclusion criteria were studied in private clinics of some psychiatrists in Isfahan city. The patients were randomly and double-blindly examined in two groups of the Iranian and imported drugs (2 and 1, respectively) at a dose of 6 mg daily every 2 weeks for 3 months. Motor and non-motor side effects were assessed using the AIMS scale. The most common non-motor effects, weight, vital signs, and blood factors were evaluated by specially prepared forms during the study. Data was analyzed statistically using SPSS software by paired t-test, Mann-Whitney, Chi-square, covariance, Fisher's exact, and Pearson's tests.

The changes in AIMS scores during the study averaged 0 ± 0 and 0.88 ± 0.5 in groups 1 and 2, respectively (p = 0.133). The mean weight changes during the study were 7.10 ± 5.1 and 5.02 ± 4.1 kg in groups 1 and 2 (p = 0.719), respectively. The two groups were not significantly different in the study's three parameters of vital signs, blood factors, and common non-motor complications. The two drugs were not statistically different regarding clinical side effects and were similar.