Comparison of serum levels of vitamin B12 and vitamin D3 in patients with oral lichen planus with healthy individuals

Background: Lichen planus or skin moss is a relatively common inflammatory disease of the skin and mucous membranes. Since lichen planus is a lesion that may sometimes have malignant changes, and more importantly, it can be differentiated from some of our premalignant and malignant lesions, so the present study aims to investigate the patients' B12 and D3 vitamins. patients with oral lichen planus and compared with healthy people.

Methods: The present study was conducted as a case-control using data from the Lichen Plan Registry of Kermanshah University of Medical Sciences. For this purpose, 43 people with oral lichen planus as a case group with a clinical diagnosis of oral lichen planus and 43 healthy people who were age- and sex-matched with the group of patients were compared in terms of serum vitamin D3 and vitamin B12 levels. The control group was randomly selected from those who referred to the Kermanshah Dental School and did not have lichen planus or other autoimmune diseases. The vitamin B12 vitamin D3 test was requested for both groups and the results of the patients' tests were compared with healthy people. The obtained information was analyzed by the Mann-Whitney test or T-test and logistic regression.

Results: In this study, 43 lichen planus patients and 43 healthy individuals were investigated as a control group. 60.5% of lichen planus patients and 58.1% of healthy people were women, which did not have a significant difference in gender distribution (P=0.826). The mean ± standard deviation of the age of lichen planus patients was 50.28 ± 15.78 years and in the control group it was 47.84 ± 15.66 years, which had no significant difference (P=0.473). The mean ± standard deviation of BMI in lichen planus patients was 24.08 ± 4.01 and in the control group it was 24.13 ± 3.01, which were not significantly different (P=0.562). The mean ± standard deviation of vitamin D level in lichen planus patients was 31.99 ± 15.42 ng/ml and in the control group it was 35.18 ± 17.31 ng/ml, which had no significant difference (=0.563). P) The mean ± standard deviation of the level of vitamin B in lichen planus patients was 498.49 ± 452.97 pg/ml and in the control group it was 472.42 ± 370.53 pg/ml, which had no significant difference (=0.660). P)

Conclusion: The effects of this look at showed that there may be no significant relationship between vitamin D level and lichen planus.