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Clinical Cancer Investigation Journal
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Year: 2018   |   Volume: 7   |   Issue: 1   |   Page: 1-8     View issue

Clinicopathological attributes of T-lymphoblastic lymphoma seen in a tertiary care centre


Leo Mathan, Anuradha Ananthamurthy
Abstract

Background and Aims: T-lymphoblastic lymphoma (T-LBL) is a type of non-Hodgkin lymphoma (NHL), the cell of origin being the precursor T cell. This study was undertaken to describe the distribution, clinical presentation, morphological spectrum, immunohistochemical profile, and outcomes in patients with LBL presenting to our institution which is a tertiary care center. Methods: A total of 41 cases of T-LBL diagnosed during a 7-year period were included in this study. These patients were stratified into T-LBL cases and T-LBL/acute lymphoblastic leukemia cases, the latter defined as those with a lymphomatous mass and more than 25% blasts in the bone marrow. Medical records were reviewed for clinical, laboratory data, imaging findings, treatment, and follow-up. The histopathology and immunohistochemistry slides were reviewed. Results: T-LBL constituted 8.4% of all NHL seen in the period. This lymphoma is most common in childhood and adolescence. Mediastinal compression and pleural effusion are very common in patients with T-LBL (65% and 40%, respectively). The morphology consists of small-to-medium sized blasts that typically are positive for CD3, CD99, and TdT. T-LBL is an aggressive disease; relapse and progression being markers of poor outcome. Conclusion: This study is a comprehensive account of T-LBL from a tertiary care center in South India which describes the distribution, clinicopathological attributes and outcome in patients with this aggressive form of NHL.

Cite this article
Vancouver
Mathan L, Ananthamurthy A. Clinicopathological attributes of T-lymphoblastic lymphoma seen in a tertiary care centre. Clin Cancer Investig J. 2018;7(1):1-8. https://doi.org/10.4103/ccij.ccij_67_17
APA
Mathan, L., & Ananthamurthy, A. (2018). Clinicopathological attributes of T-lymphoblastic lymphoma seen in a tertiary care centre. Clinical Cancer Investigation Journal, 7(1),1-8. https://doi.org/10.4103/ccij.ccij_67_17

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