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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ARTICLE
Year: 2013   |   Volume: 2   |   Issue: 4   |   Page: 325-329     View issue

Baseline characteristics predictive of malignancy among patients presenting with lymphadenopathy: A cancer center experience


Huifang Lu, Xerxes Pundole, Shana Palla, Khanh Vu
Abstract

Context: Patients who present to tertiary cancer centers solely with radiologic evidence of lymphadenopathy often are diagnosed with malignancy, but it is unclear which baseline characteristics are predictive of a cancer diagnosis. Materials and Methods: We conducted a retrospective data review to determine baseline characteristics predictive of a cancer diagnosis and the optimal follow-up time for such patients. Results: Sixty-six adult patients with lymphadenopathy were evaluated. Thirty-six patients (55%) were diagnosed with cancer; the most common type was lymphoma. Cancer was diagnosed in 94%, 79%, and 70% of patients with supraclavicular, retroperitoneal, and abdominal lymphadenopathy, respectively. Increasing age and hypertension were associated with a cancer diagnosis in the multivariate analysis. The mean time to diagnosis was 15 days (range, 1-140 days). The average follow-up time was 18 months in patients without a cancer diagnosis. Conclusions: Patients presenting solely with lymphadenopathy at a cancer center have a higher likelihood of being diagnosed with cancer if they are at least 50 years old or have hypertension. Supraclavicular lymphadenopathy is highly associated with a malignant diagnosis. We suggest that patients presenting solely with lymphadenopathy should be followed-up for at least 6 months for a definitive diagnosis.

Cite this article
Vancouver
Lu H, Pundole X, Palla S, Vu K. Baseline characteristics predictive of malignancy among patients presenting with lymphadenopathy: A cancer center experience. Clin Cancer Investig J. 2013;2(4):325-9. https://doi.org/10.4103/2278-0513.121531
APA
Lu, H., Pundole, X., Palla, S., & Vu, K. (2013). Baseline characteristics predictive of malignancy among patients presenting with lymphadenopathy: A cancer center experience. Clinical Cancer Investigation Journal, 2(4), 325-329. https://doi.org/10.4103/2278-0513.121531

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ISSN: Print -2278-1668, Online - 2278-0513