Aspirin inhibits breast cancer progression via the switch of epithelial-mesenchymal into mesenchymal-epithelial event

Metastatic breast cancer disease is one of the leading causes of cancer-related death among women worldwide. Meanwhile, it is well-established that the epithelial-mesenchymal transition (EMT) is a major event in the development of cancer metastases. On the other hand, recent studies revealed that Aspirin could play an important role in preventing cancer development and its progression. Herein, we explored the effect of aspirin on breast cancer cells and EMT. We found that aspirin-treatment initiates mesenchymal to epithelial transition, which is the opposite event of EMT; thus, aspirin-treatment can potentially inhibit cancer invasion and metastasis. These data suggest that aspirin could be useful to prevent breast cancer progression as well as other human carcinomas and their metastases.