Pleomorphic liposarcoma (PLS) is a rare high-grade sarcoma that originates commonly in the extremities and on the retroperitoneum. PLS originating in the chest wall is infrequently reported in literature. One such case in an elderly man who presented with a giant anterior chest wall tumor is reported herein. The computed tomography scan of the chest helped in delineating the mass. The diagnosis was confirmed on histopathology. The tumor was managed with a radical excision with reconstruction. The patient underwent follow-up for 1 year during which no local recurrence or metastasis was found. PLS should be considered in the differential diagnosis of primary chest wall tumor.
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