A Systematic Mapping Study of Tumor Cell Released by Enzymes and Toxins

Cancers, especially of the neural tissue, are often deemed a death sentence. However, neither the cellular and molecular mechanisms nor the underlying causes are fully defined. Despite what is currently known about various types of brain tumors, it remains poorly understood how they spread and cause collateral damage to other parts of the brain. This research focuses the cerebrospinal fluid (CSF) leakage and enzymes from brain cancer cases and various secreted proteins and enzymes within the following hypothesis responsible for the breach of the blood-brain barrier. This research investigated the role of CSF in brain cancer and BBB. The research provides evidence that the leakage typically occurs at the spine level, especially in the thoracic spine region and the cardsiothoracic connection at the base of the brain. The aim is to determine the various proteins and enzymes contained within the CSF and investigated how to evaluate and specifically examine: (a) protein, (b) identity of these proteins/enzymes, (c) sequence of proteins/enzymes, and (d) identify the genes encoding these proteins/enzymes. Furthermore, the evidence that the function of CSF is breached by the components released from the tumorous tissue identifies the precise foci of this leakage and various proteins and enzymes that may be responsible for this damage. These observations perform a novel role in the detection of enzymes and toxins released by tumor cells, and a new component recognizes the type of CSF, whether it is normal CSF and proteolysis components of CSF related to tumor cells.