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   Table of Contents - Current issue
Coverpage
September-October 2021
Volume 10 | Issue 5
Page Nos. 225-268

Online since Thursday, October 28, 2021

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REVIEW ARTICLE  

Serous tubal intraepithelial carcinoma: Emerging trend in ovarian neoplasm: A must know for a pathologist p. 225
Banyameen Iqbal
DOI:10.4103/ccij.ccij_46_21  
Among all gynecological malignancies, ovarian cancer is associated with the highest rate of mortality. Most ovarian carcinomas have been suggested to originate from the ovarian surface epithelium or postovulatory inclusion cysts formed after follicular rupture and repair. Over the past decade, a new model has emerged to explain the origin of epithelial tumors of the ovary and the fallopian tube now appears to play a central role; however, there is now compelling evidence that many epithelial pelvic cancers, especially high-grade serous carcinomas of the ovary/peritoneum, begin in the mucosa of the fallopian tube as serous tubal intraepithelial carcinoma.
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ORIGINAL ARTICLES Top

Role of platelet endothelial aggregation receptor 1 polymorphisms in idiopathic thrombocytopenic purpura: Is there an association? p. 227
Sahar Najafi, Mohammad Ali Jalali Far, Gholam Abbas Kaydani, Kaveh Jaseb, Najmaldin Saki
DOI:10.4103/ccij.ccij_174_20  
Background: Genetic risk factors are implicated in the etiology and pathogenesis of immune thrombocytopenic purpura (ITP). Platelet endothelial aggregation receptor 1 (PEAR1) plays an important role in regulating megakaryopoiesis and thrombopoiesis. rs12041331 and rs12566888 single-nucleotide polymorphisms of PEAR1 are associated with megakaryocyte differentiation and platelet function. Materials and Methods: To conduct this study, 68 peripheral blood samples of patients with ITP (56 acute and 12 chronic) were collected. The amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was used to detection of rs12041331 and rs12566888 PEAR1 polymorphisms. Results: Statistically significant differences were not seen between rs12041331 and rs12566888 genotypes in acute and chronic groups (P = 0.778, P = 0.844). The frequency of rs12041331 AG/AA genotypes and the rs12566888 GT genotype was more in acute ITP patients; on the other hand, the rs12566888 TT genotype was more in the chronic group. The highest platelet counts and platelet distribution width (PDW) were related to the rs12041331 AG allele. GT and TT of rs12566888 had more PDW and platelet count, respectively. Mean platelet volume values between alleles of both the polymorphisms were constant and did not differ much. In general, no statistically significant differences were observed between genotypes of polymorphisms and platelet parameters. Conclusions: There was no association between rs12041331 and rs12566888 with platelet parameters in ITP patients and the severity of this disease. Further investigation with a larger size is recommended.
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A comparative survival study between familial and sporadic breast cancer in iranian women p. 234
Amir Shahram Yousefi Kashi
DOI:10.4103/ccij.ccij_25_21  
Background: Breast cancer (BC) is the most common cancer in Iranian women, with 13400 new cases annually. A few studies have reported that BC patients with a positive familial history had different prognoses and outcomes. The aim of the present study was to evaluate and compare survival between familial BC (FBC) patients and sporadic BC (SBC) patients in Iranian women. Materials and Metshods: In a longitudinal study, 1710 patients with complete medical records from the Cancer Research Center database were extracted and divided into two groups: The FBC group (n = 311) and the SBC group (n = 1399). Then, 5-year overall survival (OS) and 5-year disease-free survival (DFS) for these two groups were evaluated and compared. Results: The FBC group and SBC group represented 18.2% and 81.8% of all cases, with mean ages of 44.2 years and 47.7 years, respectively (P = 0.0024). There were more advanced stage and positive lymph nodes, higher grade of tumor, more positive lymphovascular invasion and P53 status and higher degrees of negative progesterone receptor status in the FBC group than in the SBC group (P = 0.0200, P = 0.0001, P = 0.0001, P = 0.0386, P = 0.0182 and P = 0.0003, respectively). In the FBC group and SBC group, the 5-year DFS was 81% and 86.5% (P = 0.0121), and the 5-year OS was 71.1% and 76.5%, respectively (P = 0.0401). Conclusions: The findings of this study showed better 5-year OS, 5-year DFS, and favorable prognostic factors in the SBT group than in the FBC group. The initial results might be helpful as better treatment modalities and careful follow-up in the FBC group.
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Epidemiology and clinical investigation of all cancer types in Kermanshah, Iran (2010–2019) p. 241
Babak Izadi, Mozaffar Aznab, Narges Eskandari Eskandari Roozbahani, Mehdi Naderi, Sedigheh Khazaei
DOI:10.4103/ccij.ccij_170_20  
Background: Epidemiological studies of cancer worldwide can help identify the prevalence of common cancers in the region and may help to organize their control. The study's purpose was to investigate the frequency of cancer in the urban and rural areas in the West of Iran in both sexes based on the pathological data from a single clinical center (2010–2019). Subjects and Methods: A cross-sectional study was designed to assess the demographic and clinical information was obtained from the pathology reports. Organs involved in cancer based on the international classification of disease 10th revision were coded. The variables extracted were sex, age, time of diagnosis, cancer site, and residency status. Quantitative and qualitative variables were analyzed with an appropriate statically analyzing test using the SPSS software. Results: Of the 7728 registered cancers (2010–2019) with mean age 58 ± 17 years, 3384 (44%) were female, 4341 (56%) were male, 2025 cases (26.2%) were rural, and 5687 cases (73.8%) were urban. Regarding the frequency of cancers and the age of diagnosing cancer, there was a statistically significant association between the two genders (P < 0.05). However, no similar conclusion was reached concerning residence status. Conclusion: The most common cancer in both genders was bladder, colorectal, and breast cancer. The frequency of cancers, despite the differences in the percentage of cancers between the two sexes, did not follow the same pattern as other cities in Iran and the world. Our study confirmed that the prevalence of cancer may follow the pattern of the geographical area.
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Knowledge and awareness assessment of dental students about malignant melanoma p. 247
Irfan Celik, Gaye Keser, Filiz Namdar Pekiner
DOI:10.4103/ccij.ccij_74_21  
Background: Epidemiological studies have shown an increased tendency to malignant melanoma worldwide. Dentistry students need comprehensive up-to-date information about malignant melanoma to give their patients correct advice. The purpose of this study is to assess 3rd, 4th, and 5th grade students' level of knowledge and awareness about malignant melanoma. Materials and Methods: In our study, a questionnaire consisting of 11 questions was applied to a total of 229 students, 93 3rd grade, 64 4th grade, and 72 5th grade students who were educated at Marmara University, Faculty of Dentistry. In this survey, students' level of knowledge and awareness was examined. Results: A total of 75 (32.75%) male and 154 (67.25%) female students were included in the study. There was a statistically significant difference between grades in terms of participation rate to the statement “Oral melanomas are more aggressive than skin involvement” (P = 0.000). Participation rate of 3rd grades (30.11%) was significantly lower than 4th grades (45.31%) and 5th grades (48.61%) (P1 = 0.004; P2=, 0.000). There was a statistically significant difference between grades in terms of participation rate to the statement “Oral melanoma lesions are usually asymptomatic” (P = 0,000). Participation rate of 3rd grades (15.05%) was significantly lower than 4th grades (39.06%) and 5th grades (58.33%) (P1 = 0.002; P2 = 0.000). Participation rate of 4th grades was significantly lower than 5th grades (P = 0.033). Conclusion: Providing the necessary training on malignant melanoma will improve the knowledge and awareness of dentistry students.
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CASE REPORTS Top

A rare case of compartmentalized presentation of extradural meningioma p. 254
Sarang Gotecha, Prashant Punia, Ashish Chugh
DOI:10.4103/ccij.ccij_6_21  
Meningioma is a common benign intracranial neoplasm. The incidence of its extracranial extension is rare. Of the meningioma types, meningothelial variety is the most common histological type. Authors report a case of compartmentalized presentation of extradural meningioma in a 35-year-old male who presented to us with a frontal region swelling (exostosis). The patient was evaluated with computed tomography scan of the brain. At surgery, he was found to have compartmentalized presentation of the scalp, calvarium, and dura which we would like to report in this case.
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Extensive squamous metaplasia in minor salivary gland neoplasm mimicking squamous cell carcinoma: Diagnostic dilemma in aspiration cytology p. 257
Renu Sukumaran, Nileena Nayak, Rari P Mony
DOI:10.4103/ccij.ccij_145_20  
The surgical management of salivary gland lesions depends on cytology diagnosis, in conjunction with clinical findings and imaging studies. It is extremely important to differentiate benign and malignant salivary gland lesions preoperatively. The distinction can be challenging in aspiration cytology due to metaplastic changes, cystic changes, variable cellular components within the lesions, variants of neoplasms, and sampling issues. We are presenting the case of a 42-year-old female patient who presented with a nodular lesion in the hard palate. Fine-needle aspiration cytology of the lesion was cellular and showed sheets and singly scattered squamous cells with minimal cytological atypia. As the differential diagnosis included variety of lesions ranging from nonneoplastic lesions to benign and malignant neoplasms, surgery under frozen section control was advised. Frozen sections also showed extensive squamous areas. A minor component showing bilayered ductal pattern in a background of chondromyxoid stroma also noted. Diagnosis of a salivary gland neoplasm, possibly pleomorphic adenoma with extensive squamous metaplasia was given. Although squamous metaplasia has been reported in salivary gland neoplasms, it is extremely rare to find extensive squamous metaplasia enough to cause significant diagnostic confusion. The awareness of this extensive squamous metaplasia in benign salivary gland lesions help to distinguish it from malignant lesions and to avoid unnecessarily aggressive therapy.
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Extraosseous Ameloblastoma of the buccal mucosa: A case report of a rare entity p. 260
Ashwini Munnangi, Abhimanyu Kadapathri, Nikita Oza, Vidya Bhushan
DOI:10.4103/ccij.ccij_101_20  
Extraosseous ameloblastoma is the peripheral counterpart of the usual well known central ameloblastoma. The most commonly involved sites include the lingual gingiva of the mandible, lips, and palate, with only a few reports of peripheral ameloblastoma in the buccal mucosa cited in the literature. This article aims to describe a case of peripheral ameloblastoma of buccal mucosa, its presentation, the dilemma in diagnosis, and management. We emphasize the need to include this rare entity in the differential diagnosis of buccal mucosal swellings.
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LETTERS TO THE EDITOR Top

Paediatric cutaneous langerhans cell histiocytosis mimicking hemangioma: A deceitful entity p. 263
Prita Pradhan, Sarojini Raman, Subrat Kumar Mohanty, Harish Chandra Tudu, Kanakalata Dash
DOI:10.4103/ccij.ccij_168_20  
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Loss to follow-up in clinical trials – Implications and prevention p. 265
Satvinder Singh Bakshi, Vinoth Kumar Kalidoss
DOI:10.4103/ccij.ccij_79_21  
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Lipoblastomas at rare sites: A report of two cases p. 267
Pragati Aditya Sathe
DOI:10.4103/ccij.ccij_56_21  
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