%0 Journal Article
%T Serum level of programmed death-ligand 1 in patients with gastric cancer in Mazandaran Province as a High-Risk Region in Iran
%A Ramin Shekarriz
%A Akbar Hedayatizadeh-Omran
%A Omolbanin Amjadi
%A Reza Alizadeh-Navaei
%A Gholamali Godazandeh
%J Clinical Cancer Investigation Journal
%@ 2278-0513
%D 2021
%V 10
%N 1
%R 10.4103/ccij.ccij_128_20
%P 5-10
%X 
Background: Gastric cancer is one of the most common cancers in the world. Programmed death-ligand 1 (PD-L1) is the main ligand of the programmed death-1 receptor that plays a key role in apoptosis in patients with gastric cancer. Materials and Methods: In this study, forty gastric cancer patients and forty healthy controls were enrolled. Serum PD-L1 was measured by enzyme-linked immunosorbent assay. Results: The mean (interquartile range) value of expression level of PD-L1 was 70.6 (36.6–127.3) in patients and 47.7 (29.9–92.1) in controls. There were no significant differences in PD-L1 expression between the two groups and tumor characteristics, but there was a statistically significant difference between the high expression level of PD-L1 and gastric cancer development (P = 0.044, odds ratio = 2.77, 95% confidence interval = 1.12–6.86). Conclusions: PD-L1 level increases in gastric cancer patients, so it could be used as a predictor factor.

%U https://ccij-online.org/article/serum-level-of-programmed-death-ligand-1-in-patients-with-gastric-cancer-in-mazandaran-province-as-a-high-risk-region-in-iran-888